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CAS No.: 533-31-3

芝麻酚 Catalog No. CSN12747

Synonyms: 芝麻酚

Sesamol, a natural product isolated and purified from the seeds of Sesamum indicum, ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 signaling and blocking the NF-κB and MAPK signaling pathways.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Sesamol is a natural phenolic compound found in sesame oil. In vitro studies, sesamol could suppress the adipogenic differentiation of human mesenchymal stem cells (hMSCs) by the inhibition of ERK1/2 pathway, while would not affect its characteristics. Besides this, it was found that sesamol could induce apoptosis in HepG2 cells through impairing mitochondrial function and suppressing autophagy. In vivo studies, sesamol has the ability of protecting hematopoietic system in CB57BL/6 mice against Ionizing radiation via alleviating the DNA damage and preventing acute hematopoietic syndrome. Sesamol also contributes to the improvement of unhealthy-diet-induced learning and memory loss in C57BL/6J mice.
动物研究
剂量
Mice: 10 mg/kg, 20 mg/kg^[5] (i.p.); Rat: 2 mg/kg - 8 mg/kg^[6] (p.o.), 50 mg/kg - 200 mg/kg^[7] (p.o.)

给药途径
i.p., p.o.
参考文献

动物研究
剂量	Mice: 10 mg/kg, 20 mg/kg^[5] (i.p.); Rat: 2 mg/kg - 8 mg/kg^[6] (p.o.), 50 mg/kg - 200 mg/kg^[7] (p.o.)
给药途径	i.p., p.o.

[1] Kim M, Lee YJ, et al. Anti-adipogenic effects of sesamol on human mesenchymal stem cells. Biochem Biophys Res Commun. 2016;469(1):49-54.
[2] Liu Z, Ren B, et al. Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy. Sci Rep. 2017.
[3] Kumar A, Choudhary S, et al. Sesamol ameliorates radiation induced DNA damage in hematopoietic system of whole body γ-irradiated mice. Environ Mol Mutagen. 2018;59(1):79-90.
[4] Liu Z, Sun Y, et al. Sesamol ameliorates high-fat and high-fructose induced cognitive defects via improving insulin signaling disruption in the central nervous system. Food Funct. 2017;8(2):710-719.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.2401 mL
- 36.2004 mL
- 72.4008 mL
- 5 mM
- 1.4480 mL
- 7.2401 mL
- 14.4802 mL
- 10 mM
- 0.7240 mL
- 3.6200 mL
- 7.2401 mL

技术信息

CAS号

533-31-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C7H6O3

运输

蓝冰

分子量

138.12

别名

芝麻酚

溶解度

DMSO	100.0 mg/mL (724.0 mM)
Ethanol	100.0 mg/mL (724.0 mM)

动物实验配方

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